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In silico medicine emerges in Greece just as real classical medicine did about 2.5 millennia ago

Updated: Nov 1, 2021

Faithful to its millennia-long passion for medicine, Greece has also proved to be the contemporary cradle of the new scientific, technological and progressively clinical domain of in silico medicine (https://en.wikipedia.org/wiki/In_silico_medicine, last visited on 1 Nov. 2021).

The paper entitled "In Silico Radiation Oncology: combining novel simulation algorithms with current visualization techniques" by G.Stamatakos et al. from Greece, published in Proceedings of the IEEE, the leading journal to provide in-depth review, survey, and tutorial coverage of the technical developments in electronics, electrical and computer engineering, and computer science, (Proceedings of the IEEE, vol. 90, no. 11, pp. 1764-1777, Nov. 2002, doi: 10.1109/JPROC.2002.804685, https://ieeexplore.ieee.org/abstract/document/1046955), has been the first ever publication in which the concept of "in silico medicine" (here in its concrete paradigmatic form of "in silico radiation oncology") has been introduced, explained and demonstrated to the global scientific community. This happened in 2002.

This along with a series of subsequent publications and the development of six pioneering "Oncosimulators" (digital twins in oncology), each one for a different tumour type, led by the founder and director of the Greek In Silico Oncology and In Silico Medicine Group (https://www.in-silico-oncology.iccs.ntua.gr/) Research Professor G.Stamatakos and funded mainly by the European Commission, have marked the generation of the broader "in silico medicine" field (https://en.wikipedia.org/wiki/In_silico_medicine, last visited on 1 Nov. 2021).

Furthermore, it was in Greece and more precisely at the School of Electrical and Computer Engineering, National Technical University of Athens, that the globally first academic course on in silico medicine was created and introduced into the formal doctoral studies programme of the latter by G. Stamatakos in 2014 (https://www.vph-institute.org/news/new-postgraduate-subject-on-multiscale-cancer-modelling-and-in-silico-medicine-mscm-ism.html). This marked the transformation of in silico medicine from an exclusively research field into a formal university subject.

Of special importance regarding the great potential of in silico medicine is the recent video created by the international Virtual Physiological Human Institute (VPHi, https://www.vph-institute.org/), an advisor to the European Commission, which aims at introducing in silico medicine to the wider public and is entitled "In Silico Medicine will be the future" (https://www.youtube.com/watch?v=cse_GBcHcsc)

A key recent development marking the practical applicability of in silico medicine is the inclusion of the latter in the European Centre for Disease Prevention and Control Regulation (ECDC) (https://www.vph-institute.org/news/in-silico-medicine-is-now-in-the-ecdc-regulation.html).